R-CHOP Cancer Treatment

R-CHOP is an acronym that represents a commonly used combination chemotherapy regimen in cancer treatment.

R-CHOP consists of the following drugs:

A Typical R-CHOP Regimen

(regimens should be tailored to the individual)

  • Cycle length: 21 days
  • Number of cycles: 6-8
  • Day 1: Cyclophosphamide and Rituxan (IV); doxorubicin and vincristine (IV push)
  • Days 1-5: Prednisone (oral)

Vomit potential?

Moderately high

R-CHOP is one of the most widely used combination chemotherapy regimens in the sphere of B-cell non-Hodgkin's lymphoma since studies first began to combine the newer monoclonal antibody Rituxan with the CHOP regimen around 2005. Typically R-CHOP follows a 21-day cycle, although sometimes oncologists will use a more intense 14-day cycle.

What R-CHOP is effective for and why

In 2006, the FDA approved R-CHOP as a first-line treatment for patients with diffuse large B-cell, CD20-positive, non-Hodgkin's lymphoma (DLBCL). Since then, R-CHOP has been used in the effective treatment of a wide range of B-cell NHL subtypes, including follicular lymphoma, mantle cell lymphoma, Burkitt's lymphoma, primary mediastinal large B-cell lymphoma, primary cutaneous B-cell lymphoma, and primary central nervous system lymphoma, to name a few.

Side effects

While each patient will have his or her own experiences with the side effects of the R-CHOP regimen, it is not uncommon for patients to endure mouth sores, nausea and/or vomiting, susceptibility to infections, hair loss, fatigue, and in some cases, peripheral neuropathy. These side effects should all subside when one is finished with the regimen. Patients are encouraged to report all side effects to their oncologist or oncology team.

Sources

Significant studies relating to R-CHOP


 

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